The profile is set up to target a very specific version of Microsoft Flight Simulator, as you can see in the "Send command to this target:" setting of the commands (as the log message mentions).
It's searching for the exact window title of "Microsoft Flight Simulator - 1.8.3.0".
The exact same target is also set in the profile options, making the targeting setting in the commands redundant.
To fix this profile, the targeting setting should be removed from each individual command (I.E. the "Send command to this target:" checkbox unchecked), and the profile-level option should be set to a version-independent target, E.G. "Microsoft Flight Simulator - *", so the wildcard will account for any version.