Yes, each profile can be associated with any number of applications.
Click
, click
, on the "Profile General" tab check "Enable profile switching for the following windows or processes", enter the window or process names in the textbox below using wildcards("*") where necessary, click "OK", click "Done".
If profile switching doesn't work, check that the global option is enabled by clicking
, on the "General" tab make sure "Enable Auto Profile Switching" is checked.
Restarting VoiceAttack may also be necessary.
For more information check VoiceAttackHelp.pdf(press F1 to open it while VoiceAttack has focus) page 12 and 13.